Modification of Salmonella Typhimurium motility by the probiotic yeast strain Saccharomyces boulardii.

ABSTRACT:

Background

Motility is an important component of Salmonella enterica serovar Typhimurium (ST) pathogenesis allowing the bacteria to move into appropriate niches, across the mucus layer and invade the intestinal epithelium. In vitro, flagellum-associated motility is closely related to the invasive properties of ST. The probiotic yeast Saccharomyces boulardii BIOCODEX (S.b-B) is widely prescribed for the prophylaxis and treatment of diarrheal diseases caused by bacteria or antibiotics. In case of Salmonella infection, S.b-B has been shown to decrease ST invasion of T84 colon cell line. The present study was designed to investigate the impact of S.b-B on ST motility.

Methodology/principal findings

Experiments were performed on human colonic T84 cells infected by the Salmonella

SUBMITTER: Pontier-Bres R 

PROVIDER: S-EPMC3307767 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature