Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction: cohort study.

ABSTRACT:

Objective

To assess the relation between troponin concentration, assay precision, and clinical outcomes in patients with suspected acute coronary syndrome.

Design

Cohort study.

Setting

Tertiary centre in Scotland.

Participants

2092 consecutive patients admitted with suspected acute coronary syndrome were stratified with a sensitive troponin I assay into three groups (<0.012, 0.012-0.049, and ≥0.050 µg/L) based on the 99th centile for troponin concentration (0.012 µg/L; coefficient of variation 20.8%) and the diagnostic threshold (0.050 µg/L; 7.2%).

Main outcome measure

One year survival without events (recurrent myocardial infarction, death) in patients grouped by troponin concentration.

Results

Troponin I concentrations were <0.012 µg/L in 988 pa

SUBMITTER: Mills NL 

PROVIDER: S-EPMC3307810 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature