Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.

ABSTRACT:

Background

Evolutionarily conserved genes and their associated molecular pathways can serve as a translational bridge between human and mouse research, extending our understanding of biological pathways mediating individual differences in behavior and risk for psychopathology.

Methods

Comparative gene array analysis in the amygdala and cingulate cortex between the serotonin transporter knockout mouse, a genetic animal model replicating features of human depression, and existing brain transcriptome data from postmortem tissue derived from clinically depressed humans was conducted to identify genes with similar changes across species (i.e., conserved) that may help explain risk of depressive-like phenotypes. Human neuroimaging analysis was then used to investigate the impact o

SUBMITTER: Joeyen-Waldorf J 

PROVIDER: S-EPMC3307939 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature