Expanding whole exome resequencing into non-human primates.

ABSTRACT:

Background

Complete exome resequencing has the power to greatly expand our understanding of non-human primate genomes. This includes both a better appreciation of the variation that exists in non-human primate model species, but also an improved annotation of their genomes. By developing an understanding of the variation between individuals, non-human primate models of human disease can be better developed. This effort is hindered largely by the lack of comprehensive information on specific non-human primate genetic variation and the costs of generating these data. If the tools that have been developed in humans for complete exome resequencing can be applied to closely related non-human primate species, then these difficulties can be circumvented.

Results

Using a human whole

SUBMITTER: Vallender EJ 

PROVIDER: S-EPMC3308050 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature