Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy.

ABSTRACT:

Objectives

Previous workers have demonstrated that controlled mechanical ventilation results in diaphragm inactivity and elicits a rapid development of diaphragm weakness as a result of both contractile dysfunction and fiber atrophy. Limited data exist regarding the impact of pressure support ventilation, a commonly used mode of mechanical ventilation-that permits partial mechanical activity of the diaphragm-on diaphragm structure and function. We carried out the present study to test the hypothesis that high-level pressure support ventilation decreases the diaphragm pathology associated with CMV.

Methods

Sprague-Dawley rats were randomly assigned to one of the following five groups:1) control (no mechanical ventilation); 2) 12 hrs of controlled mechanical ventilation (12CMV

SUBMITTER: Hudson MB 

PROVIDER: S-EPMC3308123 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature