Annotation of functional sites with the Conserved Domain Database.

ABSTRACT: The overwhelming fraction of proteins whose sequences have been collected in comprehensive databases may never be assessed for function experimentally. Commonly, putative function is assigned based on similarity to experimentally characterized homologs, either on the level of the entire protein or for single evolutionarily conserved domains. The annotation of individual sites provides more detailed insights regarding the correspondence between sequence and function, as well as context for the interpretation of sequence variation and the outcomes of experiments. In general, site annotation has to be extracted from the published literature, and can often be transferred to closely related sequence neighbors. The National Center for Biotechnology Information's Conserved Domain Database (CDD) p

SUBMITTER: Derbyshire MK 

PROVIDER: S-EPMC3308149 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature