The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.

ABSTRACT: The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells in the niche environment. Drosophila male germline stem cells (GSCs) attach to somatic hub cells, a component of their niche, through E-cadherin-mediated adherens junctions, and orient their centrosomes toward these localized junctional complexes to carry out asymmetric divisions. Here we show that the transmembrane receptor tyrosine phosphatase Leukocyte-antigen-related-like (Lar), which is best known for its function in axonal migration and synapse morphogenesis in the nervous system, helps maintain GSCs at the hub by promoting E-cadherin-based adhesion betw

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC3308176 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature