Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study.

ABSTRACT:

Objective

Serum α-fetoprotein (AFP) is the most commonly used biomarker for screening hepatocellular carcinoma (HCC) but fails to detect about half of the patients. Thus, we investigated if circulating microRNAs (miRNAs) could outperform AFP for HCC detection.

Design

A retrospective cohort study.

Setting

Two clinical centres in China.

Participants

The exploration phase included 96 patients with HCC who received primary curative hepatectomy, and the validation phase included 29 hepatitis B carriers, 57 patients with HCC and 30 healthy controls.

Main outcome measures

Expression of miRNAs was measured by real-time quantitative reverse transcription-PCR. Areas under receiver operating characteristic curves were used to determine the feasibility of using seru

SUBMITTER: Liu AM 

PROVIDER: S-EPMC3308260 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature