The alteration of aspart insulin pharmacodynamics when mixed with detemir insulin.

ABSTRACT:

Objective

Mixing rapid acting insulin analogs with detemir insulin to minimize daily injections has been adopted as a common regimen, especially for some children with type 1 diabetes, despite the manufacturing company's caution against mixing these analogs in the same syringe. The effect of this practice on the pharmacodynamics (PD) of rapid-acting insulin has not been widely studied. This crossover, randomized study was undertaken to determine whether mixing aspart with detemir insulin has an adverse effect on the early glucodynamic action of rapid-acting insulin analog in humans.

Research design and methods

Eight adolescents with type 1 diabetes (age 17.3 ± 0.6 years and A1C 7.3 ± 0.3%) had two euglycemic glucose clamps during which 0.2 units/kg aspart and 0.4 units/kg de

SUBMITTER: Cengiz E 

PROVIDER: S-EPMC3308292 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature