Structural and functional characterization of Bc28.1, major erythrocyte-binding protein from Babesia canis merozoite surface.

ABSTRACT: Babesiosis (formerly known as piroplasmosis) is a tick-borne disease caused by the intraerythrocytic development of protozoa parasites from the genus Babesia. Like Plasmodium falciparum, the agent of malaria, or Toxoplasma gondii, responsible for human toxoplasmosis, Babesia belongs to the Apicomplexa family. Babesia canis is the agent of the canine babesiosis in Europe. Clinical manifestations of this disease range from mild to severe and possibly lead to death by multiple organ failure. The identification and characterization of parasite surface proteins represent major goals, both for the understanding of the Apicomplexa invasion process and for the vaccine potential of such antigens. Indeed, we have already shown that Bd37, the major antigenic adhesion protein from Babesia divergens, t

SUBMITTER: Yang YS 

PROVIDER: S-EPMC3308747 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature