CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow.

ABSTRACT:

Objective and methods

A loss-of-function cytosine (C) for thymidine (T) transition at nucleotide 8590 of CYP4A11 has been associated with increased blood pressure in humans. We tested the hypothesis that CYP4A11 T8590C genotype is associated with salt sensitivity in the International Hypertensive Pathotype cohort.

Results

CYP4A11 T8590C genotype was associated with hypertension in whites. Among normotensive individuals, CYP4A11 T8590C genotype was associated with mean arterial pressure (MAP) during both high and low salt diets, such that there was no relationship between genotype and salt sensitivity of blood pressure. Among hypertensive individuals, CYP4A11 T8590C genotype did not associate with MAP during high salt intake, whereas MAP decreased with increasing number of C

SUBMITTER: Williams JS 

PROVIDER: S-EPMC3309034 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature