Genetic variants in potassium channels are associated with type 2 diabetes in a Mongolian population.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) have identified more than 40 common sequence variants associated with type 2 diabetes (T2D). However, the results are not always the same in populations with differing genetic backgrounds. In the present study, we evaluated a hypothesis that a North Asian population living in a geographic area with unusually harsh environmental conditions would develop unique genetic risks.

Methods

A population-based association study was performed with 21 single-nucleotide polymorphisms (SNPs) in nine genes selected according to the results of GWAS conducted in other populations. The study participants included 393 full-heritage Mongolian individuals (177 diagnosed with T2D and 216 matched controls). Genotyping was performed by TaqMan

SUBMITTER: Odgerel Z 

PROVIDER: S-EPMC3309067 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature