The sensitivity of lung disease surrogates in detecting chest CT abnormalities in children with cystic fibrosis.

ABSTRACT:

Rationale

Chest CT scans detect structural abnormalities in children with cystic fibrosis (CF), even when pulmonary function tests (PFTs) are normal. The use of chest CT is limited in clinical practice, because of concerns over expense, increased resource utilization, and radiation exposure. Quantitative chest radiography scores are useful in detecting mild lung disease, but whether they are sensitive to the presence of CT scan abnormalities has not been evaluated.

Objective

To determine in a cross-sectional study if quantitative chest radiography is a more sensitive marker of chest CT abnormalities than other lung disease surrogates.

Methods

Brody chest CT scores were calculated for 81 children enrolled in the Wisconsin CF Neonatal Screening Project. We determined th

SUBMITTER: Sanders DB 

PROVIDER: S-EPMC3309112 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature