Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.

ABSTRACT: Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.

SUBMITTER: Agasti SS 

PROVIDER: S-EPMC3309171 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature