Ontology highlight
ABSTRACT:
SUBMITTER: Ho PC
PROVIDER: S-EPMC3309172 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Nature immunology 20120304 4
Tolerance to endotoxins that is triggered by prior exposure to Toll-like receptor (TLR) ligands provides a mechanism with which to dampen inflammatory cytokines. The receptor-interacting protein RIP140 interacts with the transcription factor NF-κB to regulate the expression of genes encoding proinflammatory cytokines. Here we found lipopolysaccharide stimulation of kinase Syk-mediated tyrosine phosphorylation of RIP140 and interaction of the NF-κB subunit RelA with RIP140. These events resulted ...[more]