Determining the Gaussian curvature modulus of lipid membranes in simulations.

ABSTRACT: The Gaussian curvature modulus κ¯ of lipid bilayers likely contributes more than 100 kcal/mol to every cellular fission or fusion event. This huge impact on membrane remodeling energetics might be a factor that codetermines the complex lipid composition of biomembranes through tuning of κ¯. Yet, its value has been measured only for a handful of simple lipids, and no simulation has so far determined it better than a factor of two, rendering a systematic investigation of such enticing speculations impossible. Here we propose a highly accurate method to determine κ¯ in computer simulations. It relies on the interplay between curvature stress and edge tension of partially curved axisymmetric membrane disks and requires determining their closing probability. For a simplified lipid model we obta

SUBMITTER: Hu M 

PROVIDER: S-EPMC3309410 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature