Prefrontal dopamine and the dynamic control of human long-term memory.

ABSTRACT: Dopaminergic projections to the prefrontal cortex support higher-order cognitive functions, and are critically involved in many psychiatric disorders that involve memory deficits, including schizophrenia. The role of prefrontal dopamine in long-term memory, however, is still unclear. We used an imaging genetics approach to examine the hypothesis that dopamine availability in the prefrontal cortex selectively affects the ability to suppress interfering memories. Human participants were scanned via functional magnetic resonance imaging while practicing retrieval of previously studied target information in the face of interference from previously studied non-target information. This retrieval practice (RP) rendered the non-target information less retrievable on a later final test-a phenomenon

SUBMITTER: Wimber M 

PROVIDER: S-EPMC3309522 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature