Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients.

ABSTRACT: Major depressive disorder (MDD) is a leading cause of disability worldwide and results tragically in the loss of almost one million lives in Western societies every year. This is due to poor understanding of the disease pathophysiology and lack of empirical medical tests for accurate diagnosis or for guiding antidepressant treatment strategies. Here, we have used shotgun proteomics in the analysis of post-mortem dorsolateral prefrontal cortex brain tissue from 24 MDD patients and 12 matched controls. Brain proteomes were pre-fractionated by gel electrophoresis and further analyzed by shotgun data-independent label-free liquid chromatography-mass spectrometry. This led to identification of distinct proteome fingerprints between MDD and control subjects. Some of these differences were valida

SUBMITTER: Martins-de-Souza D 

PROVIDER: S-EPMC3309534 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature