The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models.

ABSTRACT: A compelling association has been observed between cardiovascular disease (CVD) and depression, suggesting individuals with depression to be at significantly higher risk for CVD and CVD-related mortality. Systemic immune activation, hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, arterial stiffness and endothelial dysfunction have been frequently implicated in this relationship. Although a differential epidemiological association between CVD and depression subtypes is evident, it has not been determined if this indicates subtype specific biological mechanisms. A comprehensive systematic literature search was conducted using PubMed and PsycINFO databases yielding 147 articles for this review. A complex pattern of systemic immune activation, endothelial dysfunction and HPA axis hype

SUBMITTER: Baune BT 

PROVIDER: S-EPMC3309537 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature