Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus.

ABSTRACT: Bacteria have evolved a variety of mechanisms for developing community-based biofilms. These bacterial aggregates are of clinical importance, as they are a major source of recurrent disease. Bacterial surface fibers (pili) permit adherence to biotic and abiotic substrates, often in a highly specific manner. The Escherichia coli common pilus (ECP) represents a remarkable family of extracellular fibers that are associated with both disease-causing and commensal strains. ECP plays a dual role in early-stage biofilm development and host cell recognition. Despite being the most common fimbrial structure, relatively little is known regarding its biogenesis, architecture, and function. Here we report atomic-resolution insight into the biogenesis and architecture of ECP. We also derive a structura

SUBMITTER: Garnett JA 

PROVIDER: S-EPMC3309717 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature