Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population.

ABSTRACT:

Aim

To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.

Methods

In this case-control study, polymorphism at TLR2 -196 to -174 del was investigated by using the allele-specific polymerase chain reaction (PCR) method, while the PCR-restriction fragment length polymorphism technique was carried out to identify the TLR4 (rs4986790 and rs4986791) genotypes in 607 Brazilian individuals (208 with chronic gastritis-CG, 174 with gastric cancer-GC and 225 controls -C).

Results

The single nucleotide polymorphisms T

SUBMITTER: de Oliveira JG 

PROVIDER: S-EPMC3309913 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature