The establishment of a bank of stored clinical bone marrow stromal cell products.

ABSTRACT:

Background

Bone marrow stromal cells (BMSCs) are being used to treat a variety of conditions. For many applications a supply of cryopreserved products that can be used for acute therapy is needed. The establishment of a bank of BMSC products from healthy third party donors is described.

Methods

The recruitment of healthy subjects willing to donate marrow for BMSC production and the Good Manufacturing Practices (GMP) used for assessing potential donors, collecting marrow, culturing BMSCs and BMSC cryopreservation are described.

Results

Seventeen subjects were enrolled in our marrow collection protocol for BMSC production. Six of the 17 subjects were found to be ineligible during the donor screening process and one became ill and their donation was cancelled. Approximat

SUBMITTER: Sabatino M 

PROVIDER: S-EPMC3309931 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature