Intrauterine growth restriction is a direct consequence of localized maternal uropathogenic Escherichia coli cystitis.

ABSTRACT: Despite the continually increasing rates of adverse perinatal outcomes across the globe, the molecular mechanisms that underlie adverse perinatal outcomes are not completely understood. Clinical studies report that 10% of pregnant women will experience a urinary tract infection (UTI) and there is an association of UTIs with adverse perinatal outcomes. We introduced bacterial cystitis into successfully outbred female mice at gestational day 14 to follow pregnancy outcomes and immunological responses to determine the mechanisms that underlie UTI-mediated adverse outcomes. Outbred fetuses from mothers experiencing localized cystitis displayed intrauterine growth restriction (20-80%) as early as 48 hours post-infection and throughout the remainder of normal gestation. Robust infiltration of ce

SUBMITTER: Bolton M 

PROVIDER: S-EPMC3309957 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature