A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.

ABSTRACT:

Background

A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results.

Method and findings

We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19-1.80]. The following meta-analysis further confirmed this significant associ

SUBMITTER: Song Q 

PROVIDER: S-EPMC3310071 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature