Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach.

ABSTRACT: Exchange mechanisms across the blood-cerebrospinal fluid (CSF) barrier in the choroid plexuses within the cerebral ventricles control access of molecules to the central nervous system, especially in early development when the brain is poorly vascularised. However, little is known about their molecular or developmental characteristics. We examined the transcriptome of lateral ventricular choroid plexus in embryonic day 15 (E15) and adult mice. Numerous genes identified in the adult were expressed at similar levels at E15, indicating substantial plexus maturity early in development. Some genes coding for key functions (intercellular/tight junctions, influx/efflux transporters) changed expression during development and their expression patterns are discussed in the context of available physio

SUBMITTER: Liddelow SA 

PROVIDER: S-EPMC3310074 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature