μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer.

ABSTRACT:

Background

Preclinical studies suggest that opioids may promote tumor growth. Genetic polymorphisms have been shown to affect opioid receptor function and to modify the clinical effects of morphine. In this study we assessed the association between six common polymorphisms in the μ-opioid receptor gene, including the well known A118G polymorphism, and breast cancer survival.

Methods

A total of 2,039 women ages 23-74 yr (38% African-American, 62% European-American, 55% postmenopausal) diagnosed with breast cancer between 1993-2001 were followed through 2006. Genotyping was performed using the TaqMan platform (Applied Biosystems Inc., Foster City, CA). Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models were used to examine the association between each geno

SUBMITTER: Bortsov AV 

PROVIDER: S-EPMC3310356 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature