MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of endogenously expressed, small noncoding RNAs, which suppress its target mRNAs at the post-transcriptional level. Studies have demonstrated that miR-34a, which is a direct target of the p53 tumor suppressor gene, functions as a tumor suppressor and is associated with the tumor growth and metastasis of various human malignances. However, the role of miR-34a in osteosarcoma has not been totally elucidated. In the present study, the effects of miR-34a on osteosarcoma and the possible mechanism by which miR-34a affected the tumor growth and metastasis of osteosarcoma were investigated.

Methodology/principal finding

Over-expression of miR-34a partially inhibited proliferation, migration and invasion of osteosarcoma cells in vitro, as we

SUBMITTER: Yan K 

PROVIDER: S-EPMC3310405 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature