Characterisation of the vitreous proteome in proliferative diabetic retinopathy.

ABSTRACT:

Background

Diabetes can lead to serious microvascular complications such as proliferative diabetic retinopathy (PDR), which results in severe vision loss. The diabetes-induced alterations in the vitreous protein composition in diabetic patients with PDR may be responsible for the presence of PDR. The vitreous humour can be utilised in a variety of studies aimed toward the discovery of new targets for the treatment or prevention of PDR and the identification of novel disease mechanisms. The aim of this study was to compare the protein profile of vitreous humour from diabetic patients with PDR with that of vitreous humour from normal human eyes donated for corneal transplant.

Results

Vitreous humour from type 2 diabetic patients with PDR (n = 10) and from normal human eyes don

SUBMITTER: Wang H 

PROVIDER: S-EPMC3310785 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature