Controversies in modern evolutionary biology: the imperative for error detection and quality control.

ABSTRACT:

Background

The data from high throughput genomics technologies provide unique opportunities for studies of complex biological systems, but also pose many new challenges. The shift to the genome scale in evolutionary biology, for example, has led to many interesting, but often controversial studies. It has been suggested that part of the conflict may be due to errors in the initial sequences. Most gene sequences are predicted by bioinformatics programs and a number of quality issues have been raised, concerning DNA sequencing errors or badly predicted coding regions, particularly in eukaryotes.

Results

We investigated the impact of these errors on evolutionary studies and specifically on the identification of important genetic events. We focused on the detection of asymmetric

SUBMITTER: Prosdocimi F 

PROVIDER: S-EPMC3311146 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature