A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome.

ABSTRACT:

Aim

To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome (MetS).

Methods

Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination (AP) consisting of berberine, policosanol and red yeast rice, in a prospective, double-blind, placebo-controlled study. Evaluations were performed at baseline and after 18 wk of treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) index was the primary outcome measure. Secondary endpoints included lipid panel, blood glucose and insulin fasting, after a standard mixed meal and after an oral glucose tolerance test (OGTT), flow-mediated dilatio

SUBMITTER: Affuso F 

PROVIDER: S-EPMC3312235 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature