Synthesis of pyrido[1,2-a]indole malonates and amines through aryne annulation.

ABSTRACT: Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.

SUBMITTER: Rogness DC 

PROVIDER: S-EPMC3312378 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature