Iontophoresis from a micropipet into a porous medium depends on the ζ-potential of the medium.

ABSTRACT: Iontophoresis uses electricity to deliver solutes into living tissue. Often, iontophoretic ejections from micropipets into brain tissue are confined to millisecond pulses for highly localized delivery, but longer pulses are common. As hippocampal tissue has a ζ-potential of approximately -22 mV, we hypothesized that, in the presence of the electric field resulting from the iontophoretic current, electroosmotic flow in the tissue would carry solutes considerably farther than diffusion alone. A steady state solution to this mass transport problem predicts a spherically symmetrical solute concentration profile with the characteristic distance of the profile depending on the ζ-potential of the medium, the current density at the tip, the tip size, and the solute electrophoretic mobility and dif

SUBMITTER: Guy Y 

PROVIDER: S-EPMC3312800 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature