Longitudinal progression trajectory of GFR among patients with CKD.

ABSTRACT:

Background

The traditional paradigm of glomerular filtration rate (GFR) progression in patients with chronic kidney disease (CKD) is a steady nearly linear decline over time. We describe individual GFR progression trajectories over 12 years of follow-up in participants in the African American Study of Kidney Disease and Hypertension (AASK).

Study design

Longitudinal observational study.

Setting & participants

846 AASK patients with at least 3 years of follow-up and 8 GFR estimates.

Measurements

Longitudinal GFR estimates from creatinine-based equations.

Predictors

Patient demographic and clinical features.

Outcomes

Probability of a nonlinear trajectory and probability of a period of nonprogression calculated for each patient from a Bayesian model

SUBMITTER: Li L 

PROVIDER: S-EPMC3312980 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature