Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.

ABSTRACT: Keloid represents overgrowth of granulation tissue, which is characterized by collection of atypical fibroblasts with excessive deposition of extracellular matrix components, after skin injury, but its etiology is still largely unknown. We recently performed genome-wide association study (GWAS) of keloid and identified NEDD4 to be one of candidate molecules associated with keloid susceptibility. Here we demonstrate a possible mechanism of NEDD4 involvement in keloid formation through enhancement of the proliferation and invasiveness of fibroblasts as well as upregulation of type 1 collagen expression. Activation of NEDD4 affected subcellular localization and protein stability of p27 which was implied its critical role in contact inhibition. It also induced accumulation of β-catenin in the

SUBMITTER: Chung S 

PROVIDER: S-EPMC3313695 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature