Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas.

ABSTRACT: Among US Latinas and Mexican women, those with higher European ancestry have increased risk of breast cancer. We combined an admixture mapping and genome-wide association mapping approach to search for genomic regions that may explain this observation. Latina women with breast cancer (n= 1497) and Latina controls (n= 1272) were genotyped using Affymetrix and Illumina arrays. We inferred locus-specific genetic ancestry and compared the ancestry between cases and controls. We also performed single nucleotide polymorphism (SNP) association analyses in regions of interest. Correction for multiple-hypothesis testing was conducted using permutations (P(corrected)). We identified one region where genetic ancestry was significantly associated with breast cancer risk: 6q25 [odds ratio (OR) per Indi

SUBMITTER: Fejerman L 

PROVIDER: S-EPMC3313799 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature