NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.

ABSTRACT: A unifying feature of eukaryotic nuclear organization is genome segregation into transcriptionally active euchromatin and transcriptionally repressed heterochromatin. In metazoa, lamin proteins preserve nuclear integrity and higher order heterochromatin organization at the nuclear periphery, but no non-metazoan lamin orthologues have been identified, despite the likely presence of nucleoskeletal elements in many lineages. This suggests a metazoan-specific origin for lamins, and therefore that distinct protein elements must compose the nucleoskeleton in other lineages. The trypanosomatids are highly divergent organisms and possess well-documented but remarkably distinct mechanisms for control of gene expression, including polycistronic transcription and trans-splicing. NUP-1 is a large prot

SUBMITTER: DuBois KN 

PROVIDER: S-EPMC3313915 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature