Associations between HIV and human pathways revealed by protein-protein interactions and correlated gene expression profiles.

ABSTRACT:

Background

AIDS is one of the most devastating diseases in human history. Decades of studies have revealed host factors required for HIV infection, indicating that HIV exploits host processes for its own purposes. HIV infection leads to AIDS as well as various comorbidities. The associations between HIV and human pathways and diseases may reveal non-obvious relationships between HIV and non-HIV-defining diseases.

Principal findings

Human biological pathways were evaluated and statistically compared against the presence of HIV host factor related genes. All of the obtained scores comparing HIV targeted genes and biological pathways were ranked. Different rank results based on overlapping genes, recovered virus-host interactions, co-expressed genes, and common interactions in

SUBMITTER: Chen KC 

PROVIDER: S-EPMC3313983 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature