Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi.

ABSTRACT:

Background

The signal recognition particle (SRP) is a ribonucleoprotein complex responsible for targeting proteins to the ER membrane. The SRP of metazoans is well characterized and composed of an RNA molecule and six polypeptides. The particle is organized into the S and Alu domains. The Alu domain has a translational arrest function and consists of the SRP9 and SRP14 proteins bound to the terminal regions of the SRP RNA. So far, our understanding of the SRP and its evolution in lower eukaryotes such as protozoa and yeasts has been limited. However, genome sequences of such organisms have recently become available, and we have now analyzed this information with respect to genes encoding SRP components.

Results

A number of SRP RNA and SRP protein genes were identified by an

SUBMITTER: Rosenblad MA 

PROVIDER: S-EPMC331402 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature