Cost-effectiveness of diacetylmorphine versus methadone for chronic opioid dependence refractory to treatment.

ABSTRACT:

Background

Although diacetylmorphine has been proven to be more effective than methadone maintenance treatment for opioid dependence, its direct costs are higher. We compared the cost-effectiveness of diacetylmorphine and methadone maintenance treatment for chronic opioid dependence refractory to treatment.

Methods

We constructed a semi-Markov cohort model using data from the North American Opiate Medication Initiative trial, supplemented with administrative data for the province of British Columbia and other published data, to capture the chronic, recurrent nature of opioid dependence. We calculated incremental cost-effectiveness ratios to compare diacetylmorphine and methadone over 1-, 5-, 10-year and lifetime horizons.

Results

Diacetylmorphine was found to be a dom

SUBMITTER: Nosyk B 

PROVIDER: S-EPMC3314060 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature