Scalable imprinting of shape-specific polymeric nanocarriers using a release layer of switchable water solubility.

ABSTRACT: There is increasing interest in fabricating shape-specific polymeric nano- and microparticles for efficient delivery of drugs and imaging agents. The size and shape of these particles could significantly influence their transport properties and play an important role in in vivo biodistribution, targeting, and cellular uptake. Nanoimprint lithography methods, such as jet-and-flash imprint lithography (J-FIL), provide versatile top-down processes to fabricate shape-specific, biocompatible nanoscale hydrogels that can deliver therapeutic and diagnostic molecules in response to disease-specific cues. However, the key challenges in top-down fabrication of such nanocarriers are scalable imprinting with biological and biocompatible materials, ease of particle-surface modification using both aqueo

SUBMITTER: Agarwal R 

PROVIDER: S-EPMC3314085 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature