Pharmacological protection from radiation ± cisplatin-induced oral mucositis.

ABSTRACT:

Purpose

To evaluate if two pharmacological agents, Tempol and D-methionine (D-met), are able to prevent oral mucositis in mice after exposure to ionizing radiation ± cisplatin.

Methods and materials

Female C3H mice, ∼8 weeks old, were irradiated with five fractionated doses ± cisplatin to induce oral mucositis (lingual ulcers). Just before irradiation and chemotherapy, mice were treated, either alone or in combination, with different doses of Tempol (by intraperitoneal [ip] injection or topically, as an oral gel) and D-met (by gavage). Thereafter, mice were sacrificed and tongues were harvested and stained with a solution of Toluidine Blue. Ulcer size and tongue epithelial thickness were measured.

Results

Significant lingual ulcers resulted from 5 × 8 Gy radiation fra

SUBMITTER: Cotrim AP 

PROVIDER: S-EPMC3314135 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature