Gastric emptying and symptoms of bulimia nervosa: effect of a prokinetic agent.

ABSTRACT:

Objective

Previous studies have suggested that delayed gastric emptying and abnormal postprandial release of hormones that influence satiation, particularly cholecystokinin (CCK), may play an important role in the pathophysiology of bulimia nervosa (BN). This study was designed to test these hypotheses as well as the efficacy of the prokinetic agent erythromycin in patients with BN.

Method

Thirty-two normal-weight women with BN and 24 control participants consumed a large liquid test meal. Gastric emptying and pre- and postprandial release of CCK, peptide YY (PYY), and ghrelin were determined. Participants with BN were then recruited for double-blind treatment with erythromycin up to 500 mg three times daily vs. placebo for 6 weeks, following which they consumed a repeat tes

SUBMITTER: Devlin MJ 

PROVIDER: S-EPMC3314137 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature