Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity.

ABSTRACT:

Purpose

Irinotecan (CPT-11) is widely used for the treatment of patients with colorectal cancer. However, the adverse effects associated with the treatment have hindered the efficacies of irinotecan. We have shown that organic selenium compounds could significantly attenuate irinotecan-associated toxicity and enhance antitumor activity in xenograft tumor models. The objective of this study is to determine the role of a specific group of uridine diphosphate glucuronosyltransferases, which is coded by UGT1A, in detoxification process of irinotecan as well as selenium-associated protective effect against irinotecan-induced toxicity.

Methods

In this study, the toxicities of irinotecan, docetaxel and cisplatin in the Ugta1 mutant rats and their wild-type controls were compared. T

SUBMITTER: Cao S 

PROVIDER: S-EPMC3314158 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature