KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.

ABSTRACT: The molecular mechanisms controlling the termination of cortical interneuron migration are unknown. Here, we demonstrate that, prior to synaptogenesis, migrating interneurons change their responsiveness to ambient GABA from a motogenic to a stop signal. We found that, during migration into the cortex, ambient GABA and glutamate initially stimulate the motility of interneurons through both GABA(A) and AMPA/NMDA receptor activation. Once in the cortex, upregulation of the potassium-chloride cotransporter KCC2 is both necessary and sufficient to reduce interneuron motility through its ability to reduce membrane potential upon GABA(A) receptor activation, which decreases the frequency of spontaneous intracellular calcium transients initiated by L-type voltage-sensitive calcium channel (VSCC) a

SUBMITTER: Bortone D 

PROVIDER: S-EPMC3314167 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature