Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.

ABSTRACT: A key step in heart development is the coordinated development of the atrioventricular canal (AVC), the constriction between the atria and ventricles that electrically and physically separates the chambers, and the development of the atrioventricular valves that ensure unidirectional blood flow. Using knock-out and inducible overexpression mouse models, we provide evidence that the developmentally important T-box factors Tbx2 and Tbx3, in a functionally redundant manner, maintain the AVC myocardium phenotype during the process of chamber differentiation. Expression profiling and ChIP-sequencing analysis of Tbx3 revealed that it directly interacts with and represses chamber myocardial genes, and induces the atrioventricular pacemaker-like phenotype by activating relevant genes. Moreover, mu

SUBMITTER: Singh R 

PROVIDER: S-EPMC3314179 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature