No Evidence for a Parent-of-Origin Specific Differentially Methylated Region Linked to RASGRF1.

ABSTRACT: Imprinted genes are expressed from one parental allele in a parent-of-origin manner. This monoallelic behavior is regulated by allele-specific DNA methylation that is confined to differentially methylated regions (DMRs). To date there are over 80 known human imprinted genes of which only three are known to have paternally methylated DMRs. In mice there exists an additional paternally methylated DMR associated with Rasgrf1. The Rasgrf1 gene forms part of the MAPK signaling pathway and plays a role in long-term memory formation and growth control. A RASGRF1-associated parent-of-origin specific DMR in humans and its methylation status in sperm DNA have not been explored. The primary aim of this study was to determine whether the human RASGRF1 gene contains a DMR and whether this DMR is patern

SUBMITTER: Pitamber PN 

PROVIDER: S-EPMC3314240 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature