Chromosome 4p16.3 variant modify bladder cancer risk in a Chinese population.

ABSTRACT: A recent genome-wide association study identified a common variant (rs798766) on 4p16.3 that confers susceptibility to bladder cancer. The aim of this study was to assess whether rs798766 is associated with risk of bladder cancer in a Chinese population as well. We genotyped this variant using TaqMan technology in a case-control study of 815 histologically confirmed bladder cancer patients and 1141 controls. Normal bladder tissues adjacent to tumors were used to evaluate the functionality of rs798766 using quantitative real-time reverse transcription-polymerase chain reaction. We found that rs798766 CT/TT genotypes were associated with a significantly increased risk of bladder cancer (odds ratio = 1.36, 95% confidence interval = 1.10-1.67), compared with the CC genotype. Furthermore, rs798

SUBMITTER: Wang M 

PROVIDER: S-EPMC3314283 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature