Copper-catalyzed enantioselective intramolecular alkene amination/intermolecular Heck-type coupling cascade.

ABSTRACT: Enantioselective copper-catalyzed cyclization of γ-alkenylsulfonamides and a δ-alkenylsulfonamide in the presence of a range of vinyl arenes results in variously functionalized 2-substituted chiral nitrogen heterocycles via a formal alkene C-H functionalization process. Application of this reaction to the concise synthesis of a 5-HT(7) receptor antagonist is demonstrated.

SUBMITTER: Liwosz TW 

PROVIDER: S-EPMC3314298 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature