Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase.

ABSTRACT: Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. The effects of nicotine on energy homeostasis have been mostly pinpointed in the central nervous system, but the molecular mechanisms controlling its action are still not fully understood. The aim of this study was to investigate the effect of nicotine on hypothalamic AMP-activated protein kinase (AMPK) and its effect on energy balance. Here we demonstrate that nicotine-induced weight loss is associated with inactivation of hypothalamic AMPK, decreased orexigenic signaling in the hypothalamus, increased energy expenditure as a

SUBMITTER: Martinez de Morentin PB 

PROVIDER: S-EPMC3314364 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature