A methodology for detecting the orthology signal in a PPI network at a functional complex level.

ABSTRACT:

Background

Stable evolutionary signal has been observed in a yeast protein-protein interaction (PPI) network. These finding suggests more connected regions of a PPI network to be potential mediators of evolutionary information. Because more connected regions of PPI networks contain functional complexes, we are motivated to exploit the orthology relation for identifying complexes that can be clearly attributed to such evolutionary signal.

Results

We proposed a computational methodology for detecting the orthology signal present in a PPI network at a functional complex level. Specifically, we examined highly functionally coherent putative protein complexes as detected by a clustering technique in the complete yeast PPI network, in the yeast sub-network which spans only ortholo

SUBMITTER: Jancura P 

PROVIDER: S-EPMC3314571 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature